NEWS

Zylera Pharmaceuticals Announces Trade Launch of BONISARA for the Treatment of Osteoporosis

October 30, 2006

Research Triangle Park, North Carolina – October 30, 2006 - Zylera Pharmaceuticals announced today the availability of BONISARA™ (strontium gluconate 680mg and ranamine 30mg) for the treatment of osteoporosis.

“We are extremely pleased to announce the introduction of BONISARA for the treatment of osteoporosis,” said Dr. Philip Tabbiner, chief executive officer of Zylera Pharmaceuticals. “In the United States, an estimated 10 million people have osteoporosis and another 34 million have low bone mass. Unlike most products currently available to treat osteoporosis, BONISARA builds tissue and prevents bone loss without some of the side effects seen with other treatments.”

About BONISARA

BONISARA is a proprietary form of strontium, which has been shown in extensive clinical trials to have a unique mechanism of action that operates on both pathways—bone loss and bone formation. The strontium in BONISARA works to stimulate the replication of osteoprogenitor cells and collagens as well as non-collagenic protein synthesis in osteoblasts, thereby enhancing bone formation. Additionally, the unique chemical makeup of BONISARA also works to foster a decrease in bone loss at the cellular and tissue level.

About Zylera Pharmaceuticals

Zylera is a specialty pharmaceutical company focused on developing medications that will treat multiple diseases arising within the inflammation and immunosuppressive pathways. Its near-term pipeline includes products for diabetes, elevated cholesterol, osteoporosis, and osteoarthritis, utilizing proprietary and patented chemical entities designed to restore key metabolic processes. Chief among these is Cytac, a carbonyl-trapping agent. Zylera is based in Research Triangle Park, NC.

FOR IMMEDIATE RELEASE Media Contact:
Susan Preston, TRx Pharma
Office: (919) 313-3568

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